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Our scientific approach is based on 3 key principles.

The Science Behind 3X4 (1:53)

Systems approach

Our bodies are complex. 3X4 looks at how our genes work together in cellular pathways and functional systems to control processes such as inflammation, metabolism and detoxification.

Going upstream

Traditionally, we have spent far too much time focusing on and trying to fix symptoms. At 3X4, we want to change this by understanding what’s happening at a deep cellular level so we can prevent, delay or reverse disease.

Sustainable change

We believe that health is not a static condition, but a daily choice. Using our Blueprint and the guidance of an expert practitioner you can gain a deeper understanding of your body and the daily choices you need to make.

It’s not about patching symptoms, it’s about understanding the root cause.

Your genes don’t work in isolation – they work with each other and the body’s environment. What we eat, how we move, our stress levels and our emotional lives affect how our genes behave. Understanding our individual genetic blueprint can guide us to make health choices that help us to live happier, longer and better.

The science behind 3X4 is based on extensive research, combined with clinical practice to ensure that every recommendation we make is both scientifically accurate and proven to work in clinical practice.

You’re unique and complex. We really like that about you.

Our job is to give you the simple blueprint that tells you what you need to stay healthy and at peak performance.

We look at the relationships between your genes in 25 metabolic pathways in your body. This approach ensures you get comprehensive feedback with explanations, recommendations and guidelines that are unique to you.

Our Lab

We ensure that the highest standards are maintained when processing your DNA. Our lab is ISO 17025:2005 and ISO 15189:2012 accredited, ensuring that your DNA is managed under rigorous control throughout the whole process.

Your DNA
is Secure

From the time your sample is collected your DNA and data is kept securely. All of your genetic data is stored in our secure Amazon Web cloud environment. We ensure we meet the exacting requirements of POPI, GDPR and HIPAA.

The Scientist behind 3X4

In her role as Chief Science Officer, Dr Yael Joffe brings over 20 years of experience in nutrition, genetics, sound research, clinical practice and scientific integrity to 3X4.

In the rapidly-evolving discipline of nutrigenomics, Yael is globally acknowledged as a leading expert in the field.  She is a highly sought-after speaker, has co-authored two books, ‘It’s Not Just Your Genes’ and ‘Genes To Plate’, and has been published in multiple peer-reviewed scientific journals.

Yael is at the forefront of nutrigenomic education and has helped develop and supervise nutrigenomics courses around the world, including her own Manuka courses, which have trained hundreds of healthcare practitioners globally.

She is currently an Adjunct Professor, teaching Nutrigenomics at Rutgers University and MUIH.